Capital losses can offset capital gains, subject to IRS rules. In practice, that includes gains from selling concentrated stock, gains from ETFs, mutual funds, or individual stocks, capital gains distributions from funds, and certain gains from taxable liquidity events.
Losses offset gains of the same type first (short-term offsets short-term; long-term offsets long-term). If losses exceed gains of that type, they can offset the other category.
Individual tax outcomes depend on your full tax picture. Cache does not offer tax or legal advice. Coordinate with a tax professional when applying harvested losses.